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doi: 10.1016/j.devcel.2020.02.008 [DOI] [PubMed] [Google Scholar] 18.Jo SJ, Shin H, Paik SH, et al

Knocking out Nrf2 or using HO-1 antagonist reversed DOX-induced heart injury and death in mice, indicating that free iron released by heme degradation is a prerequisite for inducing heart injury